Downloads
| Brochure | Braincubator presentation |
| Manual | BRAINCUBATOR-manual |
| Application notes | Braincubator Application note – acute brain slices |
BRAINCUBATOR – prolonging the viability of tissue slices
PRECISELY REGULATES pH, TEMP & MEDIA
Stable incubation conditions, improves data consistency & reduces variability across experiments.
TISSUE VIABILITY 36 HOURS OR MORE
Maintains slice integrity & functionality for extended periods, enabling longer & more complex studies.
HALVE THE NUMBER OF ANIMALS
Provides viable tissue for two days, reduces brain slice prep time & the number of animals required for research.
Parameter |
Premium Incubator (Braincubator) |
Standard slice incubation |
| Tissue Viability | >36 h | 6-8 h |
| Bacterial growth control | permanent UVC filtration | none |
| Solution control | permanent regulation of temperature and pH, incl. Monitoring |
only temperature control |
| Animal use | down to half or less | high |
The Braincubator™ is an advanced incubation system designed to prolong the viability of thin tissue samples, including acute brain slices and wholemount retina. It achieves this by precisely regulating the temperature and pH of artificial cerebrospinal fluid (aCSF) while continuously circulating the fluid through a UVC filtration system to minimize bacterial growth.
By maintaining exceptionally low bacterial levels, the Braincubator™ significantly extends tissue lifespan, enabling researchers to perform long-duration intracellular and extracellular recordings as well as imaging experiments. The system also records and stores solution conditions, allowing for later review and verification of tissue health.
Overall, the Braincubator™ establishes a gold standard for acute slice incubation, increasing experimental time, improving reliability, and reducing the number of animals required to meet research objectives.
For further information see Braincubator.com.
Why invest in an advanced acute brain slice incubator?
Standard incubation chambers may appear cheaper, but tissue quality often deteriorates within hours. By maintaining slice viability for over 36 hours, this system enables longer recordings, improves data quality, and reduces failed experiments. The increased experimental yield can cut animal use by up to 50%, allowing laboratories to generate more data from fewer animals while quickly recovering the initial investment.
FAQ – Frequently asked questions:
What is the Braincubator™?
The Braincubator™ is an advanced incubation system designed to extend the lifespan and viability of thin tissue samples such as acute brain slices and wholemount retina.
How does the Braincubator™ work?
It precisely controls the temperature and pH of artificial cerebrospinal fluid (aCSF) while continuously circulating the solution through a UVC filtration system to minimize bacterial growth.
What types of tissue can be used with the Braincubator™?
The system is optimized for thin slice tissue, including acute brain slices and wholemount retina preparations.
How does the Braincubator™ increase the lifespan of acute brain slices?
By precisely regulating pH and temperature while using UVC filtration to stop bacterial growth, the Braincubator™ significantly prolongs tissue viability compared to traditional incubation methods.
What experiments can be performed using the Braincubator™?
The extended tissue lifespan allows for long-duration intracellular and extracellular recordings, as well as imaging experiments requiring stable conditions over many hours.
How does the UVC filtration system benefit experiments?
Continuous UVC filtration keeps bacterial levels extremely low, reducing contamination risk and helping maintain consistent experimental conditions.
Does the Braincubator™ record incubation conditions?
Yes. Temperature, pH, and other solution conditions are continuously recorded and saved, allowing researchers to review data for validation and analysis of tissue health.
How does the Braincubator™ reduce animal usage?
By extending experimental time from a single tissue sample, researchers can complete more experiments per preparation, reducing the total number of animals required.
What makes the Braincubator™ different from standard incubation systems?
The Braincubator™ combines precise environmental control, continuous UVC filtration, and condition logging, establishing a gold-standard approach to acute slice tissue incubation.
Who is the Braincubator™ designed for?
It is ideal for neuroscience researchers and laboratories conducting electrophysiology or imaging experiments that require stable, long-term tissue viability.
Is is the the advanced brain slice incubator Braincubator™ worth the money?
Yes. Standard and cheaper incubation chambers often suffer from bacterial growth and fluctuating pH levels, leading to rapid cell death. A premium acute brain slice incubator prevents this, saving money in the long run through fewer failed experiments and reduced animal usage.
